S&T

Solubility is a critical factor across a wide range of industries. In the pharmaceutical industry in particular, solubility is a decisive parameter for achieving accurate in-body drug dosing.

When solubility is low, higher drug doses may be required to secure the target bioavailability. Solubility is strongly influenced by temperature, solvent type, and the characteristics of the compound being dissolved.

Understanding the solubility of a compound is essential in the early stages of drug development and has broad implications throughout the entire process. In industries beyond pharmaceuticals — such as cosmetics and food formulations — the solubility of ingredients has a significant impact on product stability and shelf life. Solubility also plays a critical role in crystallization processes.

Solubility Parameters

The attractive forces between atoms or molecules can be described by the cohesive energy parameter, the square root of which is the Hildebrand solubility parameter.

This parameter can be used to determine whether two solutions are miscible, and in the case of gases and solids, a gas can penetrate into the bulk structure of a solid when it has a solubility parameter similar to that of the solid. This parameter is highly important for addressing challenges across a variety of industries, including drug development, cosmetic formulation, polymer blending, and pigment dispersion.

iGC-SEA is a tool capable of determining solubility parameters by varying the probe molecules or experimental temperature.

The application notes below present cases of rapid and reliable measurement of the Hildebrand solubility parameters of polymethyl methacrylate and starch.

iGC-SEA Application Note 205: The Determination of the Hildebrand Solubility Parameter of Different Starch Types by Infinite Dilution Inverse Gas Chromatography.

[Request a copy] iGC-SEA Application Note 218: The Determination of the Hildebrand Solubility Parameter of Polymethyl Methacrylate by Infinite Dilution Inverse Gas Chromatography. [Request a copy]

Recrystallization

Recrystallization is essential for obtaining high-purity products, and the selection of an appropriate recrystallization solvent is determined by the solubility of the material.

In some cases, however, recrystallization must be avoided. For example, amorphous substances such as lactose and sucrose can undergo recrystallization under high-humidity conditions, which can affect the stability and quality of the final product.

Using Dynamic Vapor Sorption (DVS) methods, these crystallization processes can be measured accurately. The application note below describes how DVS can be used to monitor the kinetics of moisture-induced crystallization in amorphous spray-dried lactose.

DVS Application Note 42: Using the DVS to Investigate Moisture-Induced Crystallization Kinetics. [Request a copy]

Solubility is a critical factor across a wide range of industries. In the pharmaceutical industry in particular, solubility is a decisive parameter for achieving accurate in-body drug dosing. When solubility is low, higher drug doses may be required to secure the target bioavailability. Solubility is strongly influenced by temperature, solvent type, and the characteristics of the compound being dissolved.

Understanding the solubility of a compound is essential in the early stages of drug development and has broad implications throughout the entire process. In industries beyond pharmaceuticals — such as cosmetics and food formulations — the solubility of ingredients has a significant impact on product stability and shelf life. Solubility also plays a critical role in crystallization processes.

Solubility Parameters

The attractive forces between atoms or molecules can be described by the cohesive energy parameter, the square root of which is the Hildebrand solubility parameter. This parameter can be used to determine whether two solutions are miscible, and in the case of gases and solids, a gas can penetrate into the bulk structure of a solid when it has a solubility parameter similar to that of the solid. This parameter is highly important for addressing challenges across a variety of industries, including drug development, cosmetic formulation, polymer blending, and pigment dispersion.

iGC-SEA is a tool capable of determining solubility parameters by varying the probe molecules or experimental temperature. The application notes below present cases of rapid and reliable measurement of the Hildebrand solubility parameters of polymethyl methacrylate and starch.

iGC-SEA Application Note 205: The Determination of the Hildebrand Solubility Parameter of Different Starch Types by Infinite Dilution Inverse Gas Chromatography. [Request a copy] iGC-SEA Application Note 218: The Determination of the Hildebrand Solubility Parameter of Polymethyl Methacrylate by Infinite Dilution Inverse Gas Chromatography. [Request a copy]

Recrystallization

Recrystallization is essential for obtaining high-purity products, and the selection of an appropriate recrystallization solvent is determined by the solubility of the material. In some cases, however, recrystallization must be avoided. For example, amorphous substances such as lactose and sucrose can undergo recrystallization under high-humidity conditions, which can affect the stability and quality of the final product.

Using Dynamic Vapor Sorption (DVS) methods, these crystallization processes can be measured accurately. The application note below describes how DVS can be used to monitor the kinetics of moisture-induced crystallization in amorphous spray-dried lactose.

DVS Application Note 42: Using the DVS to Investigate Moisture-Induced Crystallization Kinetics. [Request a copy]